Nolatrexed dihydrochloride ( AG 337; Thymitaq )

产品货号. M17332 CAS No. 152946-68-4

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

Nolatrexed dihydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity.
产品描述

Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.
同义词

AG 337; Thymitaq
通路

Others
靶点

Other Targets
受体

Thymidylate synthase
研究领域

——
适应症

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1. Hughes AN, et al. Br J Y. 2000 May;82(9):1519-27.

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